Breast CAncer STratification - Understanding the determinants of risk and prognosis of molecular breast cancer subtypes. The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develo
The B-CAST project (Breast CAncer STratification) is coordinated by the Netherlands Cancer Institute Antoni Van Leeuwenhoek and it will be conducted over five years (until September 2020). Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental...
Coordinator: Marjanka Schmidt
A distributed infrastructure for life-science information - Building a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine, agriculture, bioindustries and society
From September 2015, ‘ELIXIR-EXCELERATE’ is facilitating the integration of Europe’s bioinformatics resources, supporting all sectors of life-science R&D. It will deliver excellence to ELIXIR’s users by fast-tracking the development and deployment of essential data services. EXCELERATE funding...
Coordinator: Niklas Bloomberg
Dynamics of human genome architecture in stable and transient gene expression changes
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output...
Coordinator: Miguel Beato
Widely used in studies on: * Human Genomics * Rare Diseases   Lab protocols we can do: * Exome sequencing * Whole genome sequencing * Gene panel sequencing   Bioinformatics analysis of: * Variant identification (SNVs, Indels, CNVs) * RD-Connect Genome Phenome Analysis Platform: - Standardized...
Widely used in studies on: * Plant Genomics * Animal Genomics * Complex Diseases * Population Genomics   Lab protocols we can do: * Exome sequencing * Whole genome sequencing * Gene panel sequencing   Bioinformatics analysis of: * Variant identification (SNVs, Indels, CNVs) * Genome-wide...
Widely used in studies on: * Human Genomics * Cancer   Lab protocols we can do: * Exome sequencing * Whole genome sequencing * Gene panel sequencing * Low input DNA sequencing (FFPE)     Bioinformatics analysis of:   * Somatic variant identification (SNVs, Indels, CNVs) * Cancer cell fraction *...

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